BioQuakes

AP Biology class blog for discussing current research in Biology

Tag: social distancing

“US braces for Omicron!”…Whats all the hubbub really about?

I was studying for AP Bio one day, when I first heard about the fears around the omicron variant. All over instagram, facebook, I even received emails about it: there seems to be major concern among many, including prominent medical researchers, according to WHO.

World Health Organization Logo

“What is the omicron variant?” You may ask.  This variant was first reported from South Africa  Wednesday, November 24th. In the recent weeks, cases of infection have been increasing rapidly in South Africa, likely as a result of this mutated variant. According to WHO, this variant has a large number of concerning mutations (discussed in detail below), some of which increase the risk of infection. Luckily, current SARS-CoV-2 PCR tests still can be used as a marker in detecting this new omicron variant. Because of this fact, officials have been able to detect this variant faster than previous surges in infection cases.

OmicronDespite being able to detect this variant faster than previously, researchers are still concerned over the mutations this variant poses and the implications that could have in this pandemic. Being the fastest spreading variant yet, some of these concerns include the specific mutations on the spike proteins. As we learned before, Spike Proteins protrude from the SARS-CoV-2 cell, allowing for it to bind to receptors on the host cell. Penny Moore, a virologist at the University of the Witwatersrand in Johannesburg, South Africa, says there are more than 30 mutations to the spike protein in omicron, which could possibly make it more contagious and/or allow this variant to evade our vaccines. 

Many of the mutations detected on the omicron variant have been found in the delta and Alpha variants, and are linked to heightened infections, as well as the ability to evade infection-blocking antibodies and other immune responses. Mutations to regions of the spike protein in the omicron variant has changed the way the antibodies recognize the pathogens, hindering their ability to bind to the spike proteins. If the spike proteins have mutated and changed shape, then the antibodies will not be as effective in binding. Additionally, hints from computer modeling have revealed the omicron variant could dodge the immunity given by the T cells. However, Scientists have yet to understand the true significance of these mutations and what it means for the response to the pandemic. Penny Moore and her team hope to have their first results in two weeks. 

What does this mean for vaccine efficacy?

Solo-mrna-vaccine-4 Well, two quarantined travelers in Hong Kong have tested positive for the omicron variant despite being vaccinated using the Pfizer vaccine. Additionally, Moore says that breakthrough infections have been reported in South Africa among people who have received the vaccine. Again, researchers in South Africa will soon find whether this omicron variant causes illness that is more severe or milder than that produced by the other variants. We should hear their results soon. According to Researchers, the greater threat that this omicron variant poses beyond South Africa is unclear. In the meantime, a way to fight for a healthy future would be to continually take the measures necessary to reduce the risk of COVID-19, including proven public health measures such as wearing masks, hand hygiene, social distancing, and getting vaccinated.

Let me know your thoughts below on this new variant! Stay Safe!

 

Our Next Steps To Defeat Covid-19.

Introduction

Whether it is protection from an angry bear, a criminal on the loose, the simple flu, or for safe sex, the measures we take to ensure our safety is one of the most important steps to continue to stay healthy and safe. We must continue to educate ourselves on what actions we must take in order to keep ourselves and the people around us as safe as possible.

Recently, our society has had a lot of controversy around products like masks and their effectiveness. Although many of our methods may not guarantee complete safety, we must attempt to reduce the amount of spread of serious viruses like SARS-CoV-2.

To quickly clarify, SARS-CoV-2 is the virus that invades our bodies. When SARS-CoV-2 is able to bypass our bodies’ immune system functions and infect cells in our system, our bodies contract the disease Covid-19. If further information is desired, please refer to this study on SARS-CoV-2 and Covid-19 conducted by the US National Library of Medicine National Institutes of Health.

As we approach a whole year with the presence of Covid-19 in the United States of America, we must stop to reflect on our actions and see what we can do to prevent the virus from wreaking more havoc on our society. One of the most important factors for Covid-19’s ability to spread as much as it had, was the lack of proper protection techniques used by citizens of the United States of America.

Firstly, it is very important to understand how SARS-CoV-2 is able to transfer from person to person so easily. According to the CDC, The most common way for SARS-CoV-2 to spread is through people inhaling respiratory droplets, released through other people’s coughing, sneezing, talking, etc. into their own nose and mouth. Although much rarer, SARS-CoV-2 can sometimes be spread through airborne transmission and contact with contaminated surfaces.

Since breathing is a necessity to continue living, we obviously can’t perfectly avoid inhaling these respiratory droplets, but in what ways can we try to reduce the damage of possible Covid-19 cases in the United States of America…

Forms of Protection

According to the CDC, we can take very specific steps in order to reduce the spread of Covid-19.

To further elaborate on a few of these methods, we as a society must educate ourselves on the best and most efficient way to carry out these actions. One main example at the moment is mask usage in the United States of America. Despite constantly being told, I often see many citizens wearing their masks in ways that are strongly discouraged: some under the nose, some dangling from their ears, and some not on at all. Not only does this put their own bodies at risk of contracting Covid-19, but it also risks the health of others as well.

According to the articleStill Confused About Masks? Here’s the Science Behind How Face Masks Prevent Coronavirus” by Nina Bai, a study conducted by health affairs, compared the Covid-19 growth rate before and after a mask mandate. Nina  states that “the first five days after a mandate, the daily growth rate slowed by 0.9 percentage-points compared to the five days prior to the mandate; at three weeks, the daily growth rate had slowed by 2 percentage-points.” Another study conducted by Christopher Leffler, Edsel Ing and many more professionals also found that out of the 198 countries that they had observed the Covid-19 death rate of “those with cultural norms or government policies favoring mask-wearing had lower death rates.”  Through studies, we can observe the effectiveness of such resources and use these materials such as masks to the best of our abilities to help each other stay safe.

If you are in need of instruction on how to properly use a mask and other small important pieces of information. Please refer to the CDC’s article “How to Select, Wear, and Clean Your Mask”

Another term that many have learned this year, is the term “Social Distancing.” Although staying 6 feet apart from one another like the CDC has told us, it becomes very difficult for every day citizens to abide to this rule as we have a natural tendency to gravitate towards our peers, family and other people in our communities. In order to reduce spreading the virus to other people we must stay socially-distant from others to allow people to live their lives much more comfortably, especially considering that most cases of SARS-CoV-2 transfer are caused through inhaling respiratory droplets.

Another luxury many people don’t use properly is the sinks that are in our homes and bathrooms. I’ve seen way too many people use hand sanitizer instead of going to wash their hands for the recommended 20 seconds with soap and water. For many reasons, this practice can be extremely harmful if someone is trying to prevent the spread of SARS-CoV-2. According to the CDC, there are many cases where using regular hand sanitizer won’t be as efficient as a simple washing of hands with soap and water. For example, hand sanitizer is not as efficient on greasy and dirty hands: hands after handling food, playing sports, going fishing and many other activities that may lead to dirty hands. In cases as such, the CDC recommends using soap and water for 20 seconds. However, we must truly wash our hands by properly scrubbing our hands and not simply allow the water from the sink to run through our fingers and palms. The friction caused by scrubbing allows for the lifting of dirt, grease and microbes on your skin. Microbes are also extremely present under your nails which is why your parents always tell you to make sure to get your nails when you wash your hands. Without properly cleaning our hands and other parts of our bodies, we may accidentally bring harmful substances towards our face, where the virus may be able to easily enter our bodies. By cleaning our hands thoroughly and carefully, we significantly reduce the chances of spreading the virus to others and ourselves.

Biological Implication

The reason the CDC places so much emphasis on thoroughly washing your hands with soap and water, is so that we can make sure to keep our hands clean from any harmful substances. If someone were to only wash their hands with water, they wouldn’t be able to wash off all the non polar substances like grease and oil off of their hands. For this reason, we use soap to and water rather than only water. Due to water’s polar properties, it can only bond with other polar molecules. When one adds soap into their cleansing routine, there are two new parts being tossed into the mix. The hydrophilic heads from the soap attach to the water molecules and the hydrophobic tails of the molecule bond with the non polar substances such as grease and oil. The water then continues to carry the soap and harmful substances away from our hands as other water molecules pull them down with them as gravity takes its course. Soap, being made of lipids, shows versatility as it’s able to bond with both polar and non polar molecules and allows us to fully wash our hands with its polar and non polar qualities.

Conclusion

With proper masks, socially-distant people, clean hands and many other precautions we can make sure that the spread growth is reduced way more than it previously was. Scientists are still trying to figure out all the details themselves. They’re human beings and they’re bound to make mistakes as well, so we must be understanding and flexible when new studies and information prove claims that could help us reduce the spread of SARS-CoV-2 and Covid-19 even more. In these troubling times we must look out for each other and be strong yet malleable as we face hardships that many haven’t ever experienced before.

 

 

 

Protecting Ourselves Against COVID-19

How does COVID-19 spread?

According to this article by the CDC, there are two main ways the coronavirus spreads:

  • The inhalation/exchange of respiratory emissions from:
    • Coughing/Sneezing
    • Talking/Singing
    • Breathing
  • Touching a surface with the virus on it and (without washing hands) touching:
    • Eyes
    • Nose
    • Mouth

 

Preventing the spread of COVID-19

An article (source article) from Harvard Medical School explains everything you need to know about preventing the spread of the virus. Below is a summary of how to contribute to the prevention of the spread of the virus.

 

Protecting yourself and others:

In order to protect yourself and others from the coronavirus, you should avoid those who are infected and others if you are infected, wash your hands frequently with soap and water, avoid touching your eyes, nose, and mouth with unwashed hands, and disinfect objects that are frequently touched daily. You should also minimize travel and time spent in crowds/close quarters.

 

Washing your hands:

Whenever your hands are dirty (ex: after using the bathroom) or are going to be near your face (ex: before eating a meal), wash them with soap and water for at least 20 seconds. If you are unable to wash your hands during these times, sanitize with alcohol-based hand sanitizer. A guide for washing hands, created by the CDC, explains how to properly wash your hands in five simple steps:

  1. Run your hands under clean water until sufficiently wet, then acquire soap
  2. Rub the soap around the whole surface of your hand, between every finger, underneath every nail, etc.
  3. Keep doing this for at least 20 seconds
  4. Rinse off all the soap under clean water
  5. Dry your hands on a clean drying surface or let them air dry

 

Social Distancing:

Social distancing is when in social settings, people maintain a distance of at least 6 feet between each person. This is crucial for at least slowing down the rate of infected people, providing hospitals more time and resources to take care of infected people without being overwhelmed by a large number of patients. It’s important to note that just social distancing is not enough to prevent the spread of the virus, as respiratory emissions may linger and travel more than 6 feet when airborne. Make sure to also wear a mask and avoid the indoors and areas without air circulation while with other people.

 

Essential resources:

When grocery shopping, make sure to buy a lot of nonperishable goods to keep in case of an emergency. Make sure to wear a mask when going out, as masks prevent the spread of respiratory emissions and help prevent hands from touching faces. Wipe down surfaces such as carts and baskets before using and make sure to wash your hands after using. If you’re part of an increased risk group, try to avoid going out as much as possible.

 

Minimally useful measures:

Some individuals decide to take extra precautionary measures, but they are unnecessary for the most part. Some of these include wearing gloves and quarantining mail. In situations like these, just make sure to wash your hands after handling potentially infected objects, other measures do not help significantly.

 

Masks:

Wear a mask! The most common way the virus spreads is, as stated before, through respiratory emissions. Wearing a mask prevents these emissions from traveling throughout the environment. Even asymptomatic people may carry/spread the virus, so it is important to wear a mask no matter what. Masks should fit tightly and be worn properly, completely covering the mouth and nose. Masks are not supposed to be an alternative to the other methods of prevention but should be used in addition to the other methods.

 

Infants/Toddlers:

There is an alarming amount of young children put at risk from improper/a lack of safety measures. This article from kidshealth.org explains how to properly protect children under the age of 2 from COVID-19. First of all, babies should not wear masks. This is because since their airways are extremely small, they will have a hard time breathing and may suffocate in a mask. They may also touch their face more frequently in attempts to remove the mask, increasing their risk of infection. Since they can’t wear masks, it is important to avoid going out in public with them if possible. If unavoidable, make sure to wash or sanitize your hands before handling them and put them in a stroller with a covering.

 

An analogy based on cells and membranes:

A simple way to think about it is as if the human body were a cell. The skin is like a cell membrane and the eyes, nose, and mouth are like channels in the membrane. Wearing a mask is like closing the channels in order to keep substances out. Being in a large group of people is similar to a cell in a hypotonic solution, making it more likely for the virus to “diffuse” into your body. Socially distancing is slightly similar to a cell in a hypertonic solution, for this makes it less likely for the virus to flow into the body. To sum up, just make sure to make smart decisions, wash your hands, maintain social distancing, and wear a mask. Following these guidelines will help us protect each other until the virus is no more.

Equation About Aliens Helps Prove Masks and Social Distancing Are Necessary

Wait, do we really have to wear masks? Short answer: yes. Long answer: Absolutely yes.

It’s the debate that’s been going on since Covid-19 first reached the United States. Are masks and social distancing really necessary? Some people seem to think that it’s not, which is honestly ridiculous. There is so much proof that it is necessary, so I’m going to show it to anyone who doubts it.

According to the American Institute of Physics, the Contagion Airborne Transmission (CAT) inequality model can show how, based on how the virus spreads, masks and social distancing are effective. 

The article starts with researchers from Johns Hopkins University and the University of Mississippi employing basic concepts of fluid dynamics and factors in airborne transmission to propose the CAT inequality model. Not all factors are known, including environment variables and amount of particles needed to trigger an infection. However, it can still be used to assess relative risks. 

Airborne transmitted diseases, like influenza, can spread through the air on dust, fibers, and other microscopic particles. They can also be spread through expiratory droplets. Influenza can also be spread through secondary objects, or fomites, such as door handles or tissues. Little is known about which route is most important, though airborne transmission is harder to protect against.

When a virus like Covid-19 enters the body, the body fights off the virus. It is first fought off with innate immunity, a defense that activates immediately upon infection. It’s nonspecific and rapid. If that proves to be unsuccessful, then adaptive immunity (aka acquired immunity) develops after exposure. It is very specific, though slower. The B-cells of the immune system bind and neutralize the pathogen, while T-cells eliminate any infected cells. There are also B and T memory cells that help recognize the pathogen if a host ever gets reinfected, speeding up the immune response. However, the Covid-19 virus is new. People getting infected do not have these memory cells and the immune system needs more time to react and defend themselves. Time that the virus takes to wreak havoc on the host’s body.

These researchers are able to determine the precautions necessary to prevent transmission. According to their research, increasing physical distance does increase protection. Author Rajat Mittal says doubling your distance generally doubles your protection. The scientists have also found masks to be protective. A simple cloth mask can provide significant protection and reduce the spread of Covid-19.

Physical activity that increases breathing rate and volume of people are still issues when it comes with transmission, which is why reopening schools, malls, and gyms have hard implications.

The CAT inequality model is inspired by the Drake equation in astrobiology. The Drake equation is a formula that gives us an idea about how many alien societies exist and are detectable. The equation estimates the number of transmitting societies in the Milky Way galaxy through a factorization.

Similar to the Drake equation, the model develops a factorization based on the idea that airborne transmission occurs when a person inhales a viral dose. It includes variables added at each of the three stages of airborne transmission, including breathing rates, number of virus-carrying droplets expelled, the environment, and exposure time. This model could also apply to airborne transmission of other respiratory infections like the flu, tuberculosis, and the measles.

Researchers are continuing to look closer at face mask efficiency and transmission details in high-density of outdoor spaces. However, the CAT inequality model shows that a person is less likely to inhale a viral dose if they wear a protective mask and keep their distance.

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