BioQuakes

AP Biology class blog for discussing current research in Biology

Tag: designer babies

Crispr-Cas9 is the gateway to a new frontier in genetic engineering. Here’s The good and the bad.

For a number of years now, molecular biologists have been diving increasingly further into the field of genome editing. The latest development into the field is the emergence of CRISPR-Cas9. CRISPR-Cas9 has risen to prominence over other potential methods of genome editing due to its relatively simple construction and low cost. CRISPR-Cas9’s original primary and intended purpose was to help fix mutations within DNA, and with this it could theoretically help eradicate entire diseases. This application of CRISPR is wholly positive, however with the increasing prevalence of the technique other potential uses have been discovered, and some of these potential uses raise profound ethical questions.

One of the main concerns of people skeptical about CRISPR is their assertion that once the door to the wholesale genetic editing of offspring is open, there is no going back. This, on its own, is a reasonable concern. The ability to choose a child’s sex, eye color, hair color and skin complexion is very likely to be made available to by CRISPR in the coming years. CRISPR does not yet have the capability to influence more abstract elements of the genome, such as intelligence and athletic ability, but this may not be far off. There are legitimate concerns that this is a slippery slope towards a dystopian society similar to the one seen in the movie Gattaca, where society is stratified into two distinct classes: those who are genetically engineered and those who are not.

Another concern raised by some scientists is the overall safety of genetic editing. A potentially very hazardous negative result of CRISPR is the possibility of an “off target mutation.” An off target mutation is the result of CRISPR mutating something other than the intended part of the genome and it could have disastrous consequences. Now, many scientists believe that with further advancements in the field the likelihood of something like an off target mutation occurring could be reduced to almost zero. However, it is important to examine the risks of any new process, and the prospect of something like an off target mutation occurring is certainly noteworthy.

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CRISPR Cas9: A Pathway for Designer Babies?

Can embryo modification allow parents to “custom order a baby with Lin-Manuel Miranda’s imagination or Usain Bolt’s speed?”

https://www.pexels.com/photo/adorable-baby-baby-feet-beautiful-266011/

Within the past decade, there has been an explosion in the use of CRISPR-Cas9, a gene editing tool that allows scientists to edit parts of the genome by removing, adding, or altering sections of the DNA sequence, in science research. Yet the promising technology renews the ethical issues rooted in genetic engineering and brings up the question: of what practices and ideas could become a reality in the near future? What about designer babies– embryos that have been genetically modified to produce desirable traits, such as greater athletics or higher intelligence?

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