Recent studies have found that the interactions between the gut bacteriome and mycobiome are closely related to the development and severity of Crohn’s Disease. Crohn’s disease is an inflammatory bowel disease, that causes inflammation of the lining of your digestive tract. It can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition.
In the past, the majority of studies have focused on the bacterial microbiota (bacteriome), and little attention has been paid to the fungal lining of the stomach (mycobiome). In a recent study, led by Professor Mahmoud A. Ghannoum from teh Center for Medical Mycology at the Case Western Reserve University in Cleveland, Ohio, has found new bacteria and fungi interactions that may play major roles in the development of Chron’s Disease. In his study, Prof. Ghannoum found an increase in possible pathogenic bacteria and a decrease in beneficial bacteria in CD patients.
Three organisms often found included the S. marcescens, C. tropicalis, and E. coli. The three organisms work together to create a bio film on the inner linings of the stomach. As we’ve learned in class, bacteria are unicellular organisms. They have no nuclear membrane, making them Prokaryotic. The three organisms C. tropicalis, S. marescens and E. coli were highly correlated in individuals with CD and may be key determinants of CD development.
I found this study fascinating because it brings us one step closer to discovering the possible causes of Crohn’s Disease. Approximately 1.6 million Americans suffer from Crohn’s Disease. Finding a cause, would be a huge gain in trying to find a cure. Having a loved one who suffers this disease, it gives my family and I hope for a healthy and pain free future. The questions I’d have, is why do those three specific types of bacteria increase in Crohn’s patients? Or how do they get there in such large numbers?
Main link: http://www.gutmicrobiotaforhealth.com/en/gut-bacterial-fungal-community-interactions-identified-first-time-factor-crohns-disease/
Secondary sources: http://cid.oxfordjournals.org/content/44/2/256.full