BioQuakes

AP Biology class blog for discussing current research in Biology

HeLa Cells Sequenced!

Photo By: University of Arkansas
Wellcome Trust

The immortal cell, also known as HeLa cells, have been used by scientists for years for various medical research. But, until today the genome of HeLa cells was never known. Jonathan Landry and Paul Pyl, from the European Molecular Biology Laboratory in Heidelberg, performed the study to sequence Henrietta Lacks‘ genome, and what they found was quite remarkable. They found striking differences between her cells and the cells of a normal human being. The genome had abnormalities in both chromosome number and structure. They also found that countless regions of the chromosomes in each cell were arranged in the wrong order and had extra or fewer copies of genes, all telltale signs of chromosome shattering. Chromosome shattering has recently been found to be linked to 2-3% of cancers. Seeing as how Henrietta Lacks’ cells were taken from a cervical tumor, this is not a surprising find. However, because her genome had never been sequenced this was all new to Landry and Pyl. They said, “The results provide the first detailed sequence of a HeLa genome. It demonstrates how genetically complex HeLa is compared to normal human tissue. Yet, possibly because of this complexity, no one had systematically sequenced the genome, until now.” Another scientist, Lars Steinmetz, who led the project, added, “Our study underscores the importance of accounting for the abnormal characteristics of HeLa cells in experimental design and analysis, and has the potential to refine the use of HeLa cells as a model of human biology.” Although this study is nowhere near groundbreaking, it still helps to highlight the importance of the extensive differences that cell lines can have from their human references.

For more information on this study and HeLa cells in general, you can go to:http://www.science20.com/news_articles/genome_hela_cell_line_sequenced-106181

 

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1 Comment

  1. palindromeprincess

    This article caught my attention right away because I am currently reading “The Immortal Life of Henrietta Lacks” by Rebecca Skloot. The book discusses not only the medical significance of HeLa cells, but also the life of the woman they were taken from. Doctors actually took the initial sample of her cervical cancer cells in the 1950s without Henrietta’s permission; this led to major controversy involving legal rights and Henrietta’s family. I assume this discovery regarding the HeLa genome will alter the numerous studies previously done using these cells. I am curious to see how the new findings about the abnormalities will contribute to the exciting story of HeLa cells. Check out this link for more information on “The Immortal Life of Henrietta Lacks”: http://www.nytimes.com/2010/02/07/books/review/Margonelli-t.html?pagewanted=all&_r=0

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